Projects
Harnessing Single-Cell and Spatial Transcriptomics to Uncover Novel Insights into Intestinal Barrier Breach in Cirrhosis KU Leuven
Role of MUC13 signaling on epithelial barrier disruption in gastrointestinal disorders. University of Antwerp
The transmembrane mucin isoform landscape: a new paradigm in gastrointestinal barrier dysfunction (MORSE). University of Antwerp
The effect of the microbiome on nasal epithelial barrier function in chronic rhinosinusitis KU Leuven
Chronic rhinosinusitis (CRS) is characterized by mucosal inflammation in the nasal cavity and the paranasal sinuses and effects approximately 11% of the European population. CRS is generally devided into two phenotypes depending on the presence or absence of nasal polyps, namely CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Despite the available treatment strategies, up to 40% of CRS patients remain uncontrolled even ...
Study of the mechanisms involved in MUC1/MUC13-induced intestinal barrier disruption during inflammatory bowel diseases: a translational approach. University of Antwerp
Study of the mechanisms of action by which MUC1 and MUC13 affect the intestinal barrier upon inflammation in inflammatory bowel disease. University of Antwerp
Role of the intestinal microbiota and epithelial barrier function in IBS KU Leuven
The aim of the PhD project is to explore whether the presence of mucosal or systemic low-grade inflammation and an altered epithelial barrier function (intestinal permeability) influence the central nervous system. Additionally, the influence of gut microbiota (as a gut to brain signaling pathway) will be assessed in rats transferred with gut microbiota collected from faeces of IBS patients. Brain function and neuro-inflammation will be ...
Role of intestinal barrier dysfunction for the pathogenesis of spondyloarthritis Ghent University
Patients with spondyloarthritis (SpA), a chronic inflammatory rheumatic disease, usually present with an altered composition of intestinal microbiota (dysbiosis). We want to investigate how dysbiosis influences gut epithelial integrity and the subepithelial immune system. Furthermore we will correlate the local effects of dysbiosis with biomarker profiles, acting as surrogate indicators of gut inflammation and bacterial translocation.