The role of mucosal mediators and their effect on neuronal afferent signalling and intestinal permeability during postinflammatory visceral hypersensitivity: a translational study. University of Antwerp
Visceral hypersensitivity and altered intestinal permeability are common key features of two major gastrointestinal disorders, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Alterations in the density of mucosal cells, such as enterochromaffin cells and mast cells, and in their activation status and mediator release (serotonin and proteases) have been described in IBS and IBD patients. Our first aim is to investigate ...