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Scaffold hopping from privileged diazepine derivatives towards novel tricyclic motifs KU Leuven
While the benzodiazepine drug class has been amongst the most prescribed medication globally since its discovery in the 1950s, the search for structurally related biologically active compounds is of major relevance to the pharmaceutical industry. In previous work in our group, we made the serendipitous finding that diazepinedione systems can undergo a rearrangement reaction, giving rise to completely new molecules with potentially interesting ...
Genome-Wide Computational Analysis Reveals Cardiomyocyte-Specific Transcriptional CIS-Regulatory Motifs that Enable Efficient Cardiac Gene Therapy. Vrije Universiteit Brussel Ghent University KU Leuven
Gene therapy is a promising emerging therapeutic modality for the treatment of cardiovascular diseases and hereditary diseases that afflict the heart. Hence, there is a need to develop robust cardiac-specific expression modules that allow for stable expression of the gene of interest in cardiomyocytes. We therefore explored a new approach based on a genome-wide bio-informatics strategy that revealed novel cardiac-specific cis-acting regulatory ...
Trafficking of Plant Vacuolar Invertases: From a Membrane-anchored to a Soluble Status. Understanding Sorting Information in Their Complex N-terminal Motifs KU Leuven
Vacuolar invertases (VIs) are highly expressed in young tissues and organs. They may have a substantial regulatory influence on whole plant metabolism as well as on photosynthetic efficiency. Therefore, they are emerging as potentially interesting biotechnological targets to increase plant biomass production, especially under stress. On the one hand, VIs are well-known as soluble and extractable proteins. On the other hand, they contain complex ...
Flow motifs reveal limitations of the static framework to represent human interactions Ghent University
Networks are commonly used to define underlying interaction structures where infections, information, or other quantities may spread. Although the standard approach has been to aggregate all links into a static structure, some studies have shown that the time order in which the links are established may alter the dynamics of spreading. In this paper, we study the impact of the time ordering in the limits of flow on various empirical temporal ...
A novel approach to identifying regulatory motifs in distantly related genomes Institute of Tropical Medicine
Although proven successful in the identification of regulatory motifs, phylogenetic footprinting methods still show some shortcomings. To assess these difficulties, most apparent when applying phylogenetic footprinting to distantly related organisms, we developed a two-step procedure that combines the advantages of sequence alignment and motif detection approaches. The results on well-studied benchmark datasets indicate that the presented ...
Expressing Compunction: The Literary Motifs of Byzantine Katanyktic Poetry and their Religious and Scriptural Background KU Leuven
The thesis aims to study the actual influence of the Psalms on Byzantine poetry, with a special attention to penitential poems (κατανυκτικά), since this kind of poetry shares with the Psalms peculiar elements related to self-expression and contrition. The research also includes a study of Byzantine hymnography and the liturgical role played both by the Psalms and by the catanyctic hymnography in Constantinople, in particular during the Lent ...