Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology. KU Leuven
Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are among the most remarkable biomolecules since they provide the molecular basis for all life through their unique ability to store and propagate genetic information. In this information system, the genetic alphabet is formed by 4 nucleobases, each appended to a sugar moiety. Phosphodiester linkages connect successive sugars in strands of variable lengths. Natural DNA and RNA are quickly ...