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Polypharmacy and excessive polypharmacy in community-dwelling middle aged and aged adults between 2011 and 2015 KU Leuven

Laura Hellemans, Marjan van den Akker, Gijs Van Pottelbergh, Isabel Spriet, Bert Vaes, Jos Tournoy, Lorenz Van der Linden
AIMS: We aimed to assess the prevalence, components and evolution of polypharmacy and to evaluate risk factors associated with polypharmacy. METHODS: A retrospective dynamic cohort study was performed, using a primary healthcare database comprising Flemish community-dwelling adults aged ≥40 years between 2011 and 2015. Polypharmacy and excessive polypharmacy were defined as the use of 5-9 or minimum 10 different medications during ...

Influence of Bone Remodeling Rate on Quantitative Ultrasound (QUS) Parameters at the Calcaneus and DXA BMDa of the Hip and Spine in Middle Aged and Elderly European Men: The European Male Ageing Study (EMAS) KU Leuven

Steven Boonen, Evelien Gielen, Sabine Verschueren, Frank Claessens, Dirk Vanderschueren
Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men.Design: Cross-sectional population based survey.Methods: Men aged 40-79 years were recruited from population registers in 8 European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to attend for ...

Genetic Variation in Sex Hormone Genes Influences Heel Ultrasound Parameters in Middle Aged and Elderly Men: Results From the European Male Ageing Study (EMAS) KU Leuven

Steven Boonen, Dirk Vanderschueren
Abstract Genes involved in sex hormone pathways are candidates for influencing bone strength. Polymorphisms in these genes were tested for association with heel quantitative ultrasound (QUS) parameters in middle aged and elderly European Men. Men aged 40-79 years were recruited from population registers in 8 European centres for the European Male Ageing Study (EMAS). Polymorphisms were genotyped in AR, ESR1, ESR2, CYP19A1, CYP17A1, SHBG, SRD5A2, ...

Number of CAG repeats and mortality in middle aged and older men KU Leuven

Leen Antonio, Jos Tournoy, Dirk Vanderschueren
DESIGN: The androgen receptor (AR) mediates peripheral effects of testosterone. Previous data suggests an association between the number of CAG repeats in exon-1 of the AR gene and AR transcriptional activity. The aim of this analysis was to determine the association between the number of AR CAG repeats and all-cause mortality in men and the influence of testosterone level on the association. PATIENTS AND MEASUREMENTS: Follow-up data to 27 ...

Lower insulin sensitivity is related to lower relative muscle cross-sectional area, lower muscle density and lower handgrip force in young and middle aged non-diabetic men Ghent University

Tineke Gysel, Cajsa Tonoli, Sofie Pardaens, Dirk Cambier, Jean Kaufman, Hans-Georg Zmierczak, Stefan Goemaere, Bruno Lapauw, Patrick Calders
Objectives: This study investigated whether an association between insulin resistance (IR) and muscle parameters is appreciable in young healthy men, independent of obesity. Furthermore, markers of muscle metabolism and hormones/possible determinants, were explored. Methods: 358 healthy young men were divided into a less and more insulin sensitive (LIS [age=33.2 +/- 5.4, BMI=23.4 +/- 2.3] and MIS [age=35.5 +/- 5.3, BMI=28.1 +/- 3.7]) group based ...

Fecal biomarkers in Italian anthropogenic soil horizons and deposits from Middle Ages and bronze age Vrije Universiteit Brussel

Mara Bortolini, Cristiano Nicosia, Elena Argiriadis, Giulio Pojana, Yannick Devos, Dario Battistel
Archaeological excavations in urban and rural contexts often uncover dark homogeneous anthropogenic deposits, soils and soil horizons, known as Dark Earths, Cultural Layers and Anthrosols. Major scientific questions arise about the processes that lead to the formation of these soils and deposits, as they are often related to a complex combination of environmental, climatic, and anthropogenic factors. Many studies focused on the morphological and ...