The role of intestinal microbiota in the development of inflammatory bowel diseases: identification of potentially beneficial and harmful micorbiota through ex vivo organoid technology. KU Leuven
The exact pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC) remains incompletely understood, but a loss of tolerance to gut microbiota seems crucial. Interactions between host and microbiota take place at the intestinal surface which consists of intestinal stem cells (ISC), enterocytes, goblet, enteroendocrine, and Paneth cells. The differentiation of ISC into progeny cells is suggested to be disturbed in CD and UC. The impact ...