Horse owners are well aware that their horsesU+2019 welfare influences their performance potential andhealth and thus proper training and conditioning is of great importance. However, at this point,available fitness monitoring techniques such as measuring bl
To date, most human gut microbiome research focusses on the colonic microbiome and less information is present regarding the ileum microbiome. Though, the ileum microbiome plays a prominent role in the immune system and human health. The difficulties and ethical restrictions regarding in vivo sampling oppose a need for relevant models. During this project an in vitro ileum microbiome model is developed in the SHIME, Simulator of the Human ...
We here aim to study the interplay between the gut microbiome and epigenome in response to cyanobacterial stress using the water flea Daphnia magna in combination with the cyanobacterium Microcystis aeruginosa. From previous research, we know that the gut microbiome and the epigenome are involved in the stress response of Daphnia sp. to Microcystis. Yet, so far, the lack of a combined integrative approach made it impossible to establish ...
The project will study the interplay between the gut microbiome and epigenetic modifications in response to stress by using the water flea Daphnia magna in combination with the cyanobacterium Microcystis aeruginosa as a model system. From our previous research, we know that both the gut microbiome and the epigenome are involved in the stress response of Daphnia sp. to Microcystis sp. Yet the lack of a combined integrative approach makes it ...
The human intestinal microbiota has in recent years come forward as a primary target for health monitoring and modulation. Multiple research teams are rushing forward studying microbiota shifts in major diseases to identify diagnostic markers and assess disease pathogenesis. However, a sobering fact remains that the natural variation and dynamics of the gut microbiome are greatly understudied. The Flemish Gut Flora Project (FGFP) is a ...
The gut microbiome has been the focus of intense research the last few years. It is now understood how gut bacteria, in addition to host genetics, constitute a major factor in the etiology of complex disorders. With current metagenomic analysis techniques struggling to achieve the level of detail and throughput needed, we propose an integrated approach, based on our recently developed single molecule based super-resolution microscopy mapping ...
Asthma is a chronic inflammatory disease of the airways, which is increasingly seen in developed
countries. The disease is driven by an exaggerated inflammatory response to inhaled allergens such
as house dust mite (HDM), pollen and animal dander. Asthma can be caused by allergic sensitization
to HDM via the lungs but we have recently shown that sensitization to HDM can also occur via the
skin. Both sensitization routes ...
Gut microbiome research has an enormous potential in the fields of diagnostics, disease prevention, patient stratification, and therapeutic treatment. However, an enormous amount of basic research remains to be done. Upscaling and streamlining the exploration of microbiome alterations both in health and disease is urgently needed.
Processing the most common sample type for gut microbiome analysis - frozen stool samples - is far from ...