Interfering with evolution of antibiotic resistance in microbial biofilms. KU Leuven
Biofilms are a surface-attached, structured multicellular bacterial life form which is surrounded by self-produced extracellular matrix. Biofilms are the main life form of bacteria. Previous evolution experiments using biofilms showed that there is a quick generation of variation throughout the evolution experiment. Other evolution experiments using planktonic cultures supplemented with an antibiotic showed that the cultures quickly develop ...