The clarification of biomolecular architecture responsible for disease images and their treatment via optical and non-optical superresolution microscopy and spectroscopy techniques. KU Leuven
A combination of nanoresolution microscopy techniques, such as atomic force microscopy (AFM) Fluorescence Imaging with One Nanometer Accuracy (FIONA) and tip enhanced Raman spectroscopy (TERS), will be used to study the biomolecular interactions of ligands with DNA and the impact of this interaction on the DNA structure. At first the binding of lens epithelium derived growth factor (LEDGF/p75) with chromatine will be studied. The information ...