Unraveling the unprecedented roles for Presenilin/?-secretase in inter-organellar membrane contact sites and how this modulates cellular calcium homeostasis KU Leuven
Mutations in presenilin (PSEN) 1 and 2 account for the majority cases of familial Alzheimer’s disease (FAD). Since their discovery, many teams have focused on how these mutations affect PSEN’s catalytic role in producing toxic amyloid β peptides. Nevertheless, mutant PSENs have also been extensively linked to Ca2+ signaling pathways, for instance through storage compartments, like the endoplasmic reticulum (ER) and lysosomes. Ca2+ shuttling ...