Projects
ER-MITOCHONDRIA CONTACT SITES-MEDIATED LIPID TRANSFER: AT THE CROSSROAD BETWEEN LIFE AND DEATH KU Leuven
The EMCS are emerging as a key center of inter-organelle communication and organizers of crucial cellular functions. In the last years, with the identification of MCS proteins localized in diverse organelle-organelle juxtapositions, the concept of “moonlighting “proteins was introduced. The ER stress sensor PERK, besides being involved in the UPR, has been shown by our lab to be a MCS regulator, independently of its kinase activity. After ER ...
Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & disease KU Leuven
Phosphorylation status of GRP75 and its impact on MAMs dynamics and function KU Leuven
Capturing microbial diversity by single-cell phenotyping to identify governing principles of subcellular organization and unicellular proliferation KU Leuven
Capturing microbial diversity by single-cell phenotyping to identify governing principles of subcellular organization and unicellular proliferation KU Leuven
Modern metagenomics has opened our eyes to the immense microbial diversity that exists both among and within us. Despite this diversity, all microbes share a similar challenge, and that is to survive and proliferate in order to subsist in their respective environments. To achieve this, these unicellular organisms must integrate a large variety of processes in tiny compartments. Microbes need to take up and metabolize nutrients to generate ...
Understanding non-genetic processes remodelling the tumor ecosystem, cancer cell death and immune escape mechanisms KU Leuven
Efficient tumor clearance by anticancer therapies requires effective therapy-mediated debulking along with the engagement of the immune system. The induction of regulated cancer cell death (RCD) able to reinstate, rather than suppressing, anticancer immune responses -so called immunogenic cell death - is therefore a highly desirable therapeutic effect. However, the recognition and clearance of residual cancer cells by the immune system, ...