Projects
3D4Health : Protection structures for health: Structural biology of therapeutic membrane proteins as a starting point for effective rational drug design. Vrije Universiteit Brussel
Tumor-associated fatty acid synthase expression: impact on lipid composition and on functionality of membranes, role in cancer cell biology and applications for cancer intervention. KU Leuven
A general law describing the diffusion of membrane proteins in vivo based on single molecule tracking of membrane proteins in Escherichia Coli. KU Leuven
The ultimate goal of cell biology is to understand how proteins function in real cells and to understand their regulatory mechanisms. To achieve this goal one needs to analyze molecules in their cellular environment and not under idealized test tube conditions. A major difference between in vivo and in vitro conditions is the crowdedness (and associated molecular complexity) of the cytoplasm and biological membranes. As a consequence ...
What is the role of activated sludge flocs in membrane fouling build up in membrane bioreactors (MBRs)? KU Leuven
As an efficient technology for wastewater treatment, membrane bioreactors (MBRs) have gained a lot of popularity over the recent years. In an MBR, the secondary biological treatment step is combined with a pressure driven membrane filtration, which results in an effluent of consistently high quality, reliable operation and a reduced footprint in comparison with conventional activated sludge systems that rely on sedimentation. However, fouling, ...
Thermoplastic Elastomer Microfluidic Devices for Biology and Chemistry KU Leuven
Since its emergence, microfluidics has proven to be a powerful tool in chemistry and the life sciences. Microfluidic devices, consisting of networks of micron-scale flow channels, leverage high surface-area-to-volume ratios and precision fluid control to provide advantages over conventional methods in chemistry and biology. In chemistry, reactions with greater speed, selectivity, and safety can be achieved thanks to fast mixing and efficient ...
FABLITE – A light sheet microscopy and microfabrication 'ménage-àdeux' for real-time, high throughput and physiological structural biology. Hasselt University
Chemical biology approaches to confirm the druggability of neurodegeneration linked rhomboid proteases. KU Leuven
Alzheimer’s disease and Parkinson´s disease belong to a group of illnesses that cause the progressive loss of function of neurons, which leads to dementia as most common symptom. These diseases are a puzzle from which we still lack many pieces. As a result, no drug targets for these diseases are known and no cure exists. One of the missing parts of the puzzle may be a group of proteins called rhomboids. Rhomboids are found in all living ...