(Re)defining the origin and cellular niche of melanoma stem cells KU Leuven
It has been suggested that only a restricted number of cancer cells,
known as cancer stem cells (CSCs), are fated to fuel tumour growth.
As a result, these specialised cells have become the targets of
intense drug discovery efforts. In melanoma, however, whether
CSCs exist has remained unclear. Combining single-cell RNA
sequencing with in vivo lineage tracing and mathematical modelling,
we identified a population ...