Regulation of vesicular trafficking in melanoma and its driving role in melanoma plasticity and progression KU Leuven
Melanoma is the deadliest form of skin cancer due to its ability to metastasize rapidly and to become resistant to various forms of therapies. To support their aggressive phenotype, melanoma cells require metabolic plasticity, which they acquire by hijacking key adaptive responses like the hypoxia-inducible response and autophagy. On the one hand, abnormal stabilization and upregulation of Hypoxia Inducible Factor 1 alpha (HIF-1α) have been ...