Methods and media for preparing cells for healing bone and joint disorders KU Leuven
The invention relates to in vitro methods of inducing hypertrophy in chondrogenic cells comprising the step of incubating aggregates of chondrogenic cells in a medium comprising BMP4 or BMP2, a Wnt agonist and a thyroid hormone. The invention further relates to the medical use of cells obtained by this method to repair bone and joint disorders.