Understanding role of mechanical forces in human neural tube development and neural tube defects KU Leuven
The formation of the neural tube is the earliest event in the establishment of the central nervous system. Cell acquire their identity at the same time as the tissue undergoes large-scale tissue deformations, driven by cellular contractility and mechanical forces. However, the relationship between these tissue deformations, the developed mechanical forces and the establishment of cellular identities remains largely unexplored. In addition, it ...