Projects
Mass spectrometry imaging as a next generation tool in the digital pathology of prostate cancer. KU Leuven
Prostate cancer (PCa) is the most commonly diagnosed cancer in men in the developed world. Particularly stable disease control is challenging. Still in 2012, an estimated 1.1 million men worldwide were diagnosed with PCa and 307 000 men died of this disease. As prostate epithelial cells are exquisitely dependent on male sex hormones (androgens), the primary treatment for advanced PCa is suppression of androgen production, usually combined ...
Advanced 2D and 3D chemical imaging using laser ablation ICP - mass spectrometry (LA-ICP-MS) and complementary multimodal techniques via image fusion Ghent University
Laser ablation-ICP-mass spectrometry (LA-ICP-MS) can be used for visualizing the distribution of (trace) elements across any solid material with high spatial resolution. The recent development of low-dispersion LA cells has provided gains in throughput and sensitivity of 2-3 orders of magnitude compared to conventional cells. The project focuses on development of methodologies for high-resolution 2D & 3D imaging of samples of a wide range ...
Modular high-end mass spectrometer for ultrasensitive quantification and imaging of small organic molecules in cross-health research - MSsmall-XH Ghent University
The current high-throughput multi-omics technologies, complemented with revolutionary micro- and nanoscopic imaging tools, offer amazing opportunities for holistic investigation and pathophysiologic understanding of diseases in both man and animals. However, the accurate and specific quantification of small organic molecules currently faces two major challenges: 1) the increasing availability of microsamples from biological origin having ...