Projects
MALDI Mass Spectrometry Imaging (MALDI-MSI): Bridging proteomics and imaging. University of Antwerp
Challenges in mass spectrometry: computational lipidomics and MS imaging Hasselt University
Tracer Raman-Driven Mass Spectrometry Imaging (TRaMaSI): a new platform for on-tissue Tracing of Nutritional and Biochemical Trajectories. Flanders Institute for Biotechnology
Chemical Imaging of Biological Systems by Mass Spectrometry Imaging-enhanced Coherent Raman Scattering Microscopy KU Leuven
The functioning of biological systems is made possible through intricate interactions between cells that make up the tissues and the interplay between diverse classes of molecules that make up the cells. Dysregulation of this ecosystem typically leads to disease. Recent advances in spatial omics approaches have enabled a detailed mapping of the molecular composition of tissues with retention of spatial information. One of the emerging ...
Dimensionality reduction of mass spectrometry imaging with deep learning KU Leuven
Machine learning for Mass Spectrometry Imaging KU Leuven
A mass spectrometry imaging experiment results in very large, high dimensional data sets that are not easily analysed. This data contains an enormous amount of diverse information about all kinds of diseases, treatments and so on. Using machine learning techniques we want to find new insights from this data. We also want to find more efficient analysing methods for this type of data.
Method development for multi-modal imaging mass spectrometry (LA-ICP-MS and MALDI-MS): fusing elemental with molecular information to gain insight into hypoxia-driven processes in cancer Ghent University
Tumor hypoxia is one of the hallmarks of cancer and has turned into a central issue in cancer treatment since it is associated with malignant tumor progression, resistance to therapy and increased metastatic spread. To date, many aspects of hypoxia-induced changes in tumors remain to be elucidated. This drives the need to develop multi-modal imaging workflows for discovering and identifying key biomolecules in the heterogeneous tumor ...
Mass spectrometry imaging as a next generation tool in the digital pathology of prostate cancer. KU Leuven
Prostate cancer (PCa) is the most commonly diagnosed cancer in men in the developed world. Particularly stable disease control is challenging. Still in 2012, an estimated 1.1 million men worldwide were diagnosed with PCa and 307 000 men died of this disease. As prostate epithelial cells are exquisitely dependent on male sex hormones (androgens), the primary treatment for advanced PCa is suppression of androgen production, usually combined ...
Computational Mass Spectrometry Imaging of Amyloid Plaque Populations in the Brains of Non-Demented and Alzheimer's Disease Patients KU Leuven
γ-Secretase activity is involved in multiple physiological processes and plays a key role in Alzheimer’s disease (AD) pathogenesis. AD-causing mutations in Presenilin (PSEN1/2) (the catalytic core of γ-secretase) and the Amyloid Precursor Protein (APP) consistently reduce the number of γ-secretase cleavages on the APP C99 substrate, leading to production of longer amyloidogenic Aβ peptides. The pathogenic mutant effect points at the shift in ...