Projects
Identification of critical on mTOR effector pathways in NF1-related tumorigenesis Ghent University
In this project we aim to define the critical mTOR effector pathways that participate in the development of neurofibromatosis type 1 (NF1)-related tumorigenesis. Identifying critical mTOR effectors will help unravel the basic pathology of NF1 and provide important mechanistic insight into the mTOR pathway, which is deregulated in NF1 as well as a variety of cancers.
Molecular profiling of clear-cell renal cell carcinoma and prediction of response to targeted therapies against the vascular endothelial growth factor receptor, immune checkpoint inhibitors and mTOR inhibitors in the metastatic setting. KU Leuven
Over the last 10 years, several new therapies became available for the treatment of metastaticclear-cell kidney tumors: blood vessel inhibitors, mTOR-inhibitors and new generation
immunotherapy. Although these therapies have globally improved therapeutic outcome, individual
patient responses are highly variable. There is an urgent need to know in advance which therapy
will be the best for each patient in order to improve ...
The role of altered calcium and mTOR signaling in the pathogenesis of cystinosis. KU Leuven
The role of Ca and mTOR signaling in the pathogenesis of autosomal dominant polycystic disease KU Leuven
In this PhD project, on the eve of broadening the AdultDPKD horizon with ADPediatricKD, we explored the childhood ADPKD phenotype and the challenges concerning its management, in order to urge the need for a standardized and multidisciplinary approach, as many ambiguities still exist.
First, we confirmed the existence of the latter, by showing that the clinicians’ attitudes and current clinical practice are lacking an agreement ...
mTOR inhibition as a promising strategy to regress atherosclerotic plaques in mice. University of Antwerp
Spatial inattention and motor functioning after stroke: An in-depth analysis of the impact of visuospatial neglect on motor recovery. University of Antwerp
Translational Research Network in Motor Disorder Rehabilitation: Advancing understanding of variability in motor control and learning, to enhance clinical practice KU Leuven
The theoretical understanding of human motor control and learning has a strong impact on the diagnosis and treatment of motor disorders, and vice versa. Recent progress has been made in the understanding of motor control and learning, particularly with respect to understanding the functional role of neuro-behavioural variability that is inherent to sensorimotor control. However, this progress has not yet been transferred appropriately into ...