Publications
Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes Ghent University Flanders Institute for Biotechnology
A Yellow Fever 17D Virus Replicon-Based Vaccine Platform for Emerging Coronaviruses KU Leuven
Neo-Antigen mRNA Vaccines Vrije Universiteit Brussel
The interest in therapeutic cancer vaccines has caught enormous attention in recent years due to several breakthroughs in cancer research, among which the finding that successful checkpoint blockade treatments reinvigorate neo-antigen-specific T cells and that successful adoptive cell therapies are directed towards neo-antigens. Neo-antigens are cancer-specific antigens, which develop from somatic mutations in the cancer cell genome that can ...
A synthetic DNA template for fast manufacturing of versatile single epitope mRNA Vrije Universiteit Brussel
A flexible, affordable, and rapid vaccine platform is necessary to unlock the potential of personalized cancer vaccines in order to achieve full clinical efficiency. mRNA cancer vaccine manufacture relies on the rigid sequence design of multiepitope constructs produced by laborious bacterial cloning and time-consuming plasmid preparation. Here, we introduce a synthetic DNA template (SDT) assembly process, which allows cost- and time-efficient ...