Genetic defects in chromatin regulators in T-cell acute lymphoblastic leukemia Ghent University
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocy1es affecting children, adolescents and adults. T-ALL is characterized by an unequal gender distribution (male-female ratio of about 3:1). In a search for X-linked tumor suppressor genes, we previously discovered loss-of-function mutations and
deletions affecting the PHF6 gene on chromosome X in T-ALL (1). In this project, we used a candidate gene ...