Publications
24(R, S)-Saringosterol - From artefact to a biological medical agent Hasselt University
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes Institute of Tropical Medicine Ghent University
Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture, and resistance to genetic manipulation have limited their use. Here, we show that the pyrrolizidine alkaloid retrorsine improves PHH repopulation of chimeric mice on average 10-fold and rescues the ability of even poorly plateable donor hepatocytes to provide cells for ...
Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease Ghent University University of Antwerp
Distinct dopamine D2 receptor antagonists differentially impact D2 receptor oligomerization Ghent University
Androgen receptor gene copy number and protein expression in treatment-naïve prostate cancer Ghent University KU Leuven
Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas Vrije Universiteit Brussel
BACKGROUND & AIMS: Ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), down-regulates the T-cell-mediated immune response (called immune checkpoints). Antibodies that block these receptors increase antitumor immunity in patients with melanoma, non-small-cell lung cancer, and renal cell cancer. Tumor-infiltrating CD4+ and CD8+ T cells in ...
Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours Vrije Universiteit Brussel Ghent University
Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity. The Ly49 family of NK receptors is composed of several members that recognize major histocompatibility complex class I (MHC-I) or MHC-I-related molecules. Ly49E is a unique inhibitory member, ...