Projects
Airway-specific activation of Liver X Receptor for the treatment of Mycobacterium tuberculosis infection Ghent University
Research Grant Emmanuel Van de Schueren to Suzanne Vanhauwaert: BRIP1 and BIRC5 as novel therapeutic targets in neuroblastoma Ghent University
Neuroblastoma (NB) is an aggressive neural crest derived childhood tumor with poor survival rates, especially in
older children. Thus far, three bona fide oncogenic driver genes have been identified in neuroblastoma: MYCN,
amplified in roughly half of all aggressive neuroblastoma cases, ALK mutations or amplifications in 10% of cases
and rare LlN28B amplifications. Chromosome 17q gain is by far the most common ...
Linking patient adiposity to tumour microenvironment and therapy response in breast cancer: towards tailored treatment strategies in obesity KU Leuven
This thesis explores innovative translational research approaches in breast cancer, aiming to increase biological understanding of the disease and thereby help advance precision medicine. It does so in two groups of patients with a high clinical unmet need. First, it investigates patients with early breast cancer in the context of adiposity (body fat accumulation). Secondly, it investigates metastatic breast cancer, which is the ultimate ...
The interplay between endogenous inflammatory mediators and microbial components in innate immunity KU Leuven
HCV is a hepatotropic virus with a global prevalence rate of approximately 70 million individuals worldwide. Following HCV infection, the majority of individuals develop a chronic infection that is characterized by the occurrence of hepatic fibrosis and HCC. While great strides have been made understanding and treating HCV infection, there remains much to be revealed. In this thesis, we were interested in determining the role of HCV proteins ...
A whole-body physiologically based pharmacokinetic model for personalized 161Tb-PRRT KU Leuven
Peptide receptor radionuclide therapy (PRRT) has been proven to be a safe and effective treatment of somatostatin receptor expressing neuroendocrine tumours (NETs). So far, standard activities are usually injected, although it has been shown that the variable tumour burden between patients can have a high impact on the biologically effective doses (BEDs) to normal tissues and tumour tissue with large tumour loads leading to a considerably ...
IL-10 in the pathogenesis of systemic juvenile idiopathic arthritis and regulation of its production by IFN-y in TLR-triggered inflammation KU Leuven
Systemic juvenile idiopathic arthritis (sJIA) is a rare but severe childhood immune disorder and is a subtype of JIA, a heterogeneous group of arthritic diseases. In contrast to other JIA subtypes, sJIA is characterised by systemic features, such as fever, rash and enlargement of lymph nodes, spleen or liver, which are often more prominent than joint inflammation. The aetiology of sJIA remains largely unknown. One hypothesis is that sJIA ...
Tolerance and resistance to parasite infection: trypanosomatidae as paradigm (TRIT) Vrije Universiteit Brussel
The role of the 1,25(OH)2D3 signaling cascade and its analogs on inflammatory bowel disease KU Leuven
Inflammatory bowel disease (IBD) represents a group of idiopathic, chronic diseases of the gastro-intestinal tract including both Crohn’s disease (CD) and ulcerative colitis (UC). The exact etiology of IBD is still largely unknown, however, it is generally accepted that an excessive host immune response towards luminal bacteria plays a major role. A genetic predisposition, environmental factors as well as the epithelial barrier itself ...