Projects
EV-TRACE: Extracellular Vesicle Tracking using surface proteins and Resonance Assays to detect breast Cancer in Early stage Ghent University
Extracellular Vesicle Tracking using surface proteins and Resonance Assays to detect breast Cancer in Early stage (EV-TRACE) A major challenge in cancer is to detect the disease early on and it locate organ of origin while stratifying patients to receive appropriate treatment to increase survival and quality of life. Most cancers that are detected early can only be cured by surgery; so without any systemic therapy. New, inexpensive and ...
"-omics" as tool to address the burden of non-communicable age-related disease in populations in epidemiological transition KU Leuven
Summary
Background and objectives
The objective of this doctoral thesis was to explore “‑omics” technologies as a tool to address the burden of non-communicable age-related disease in populations in epidemiological transition. We choose diastolic left ventricular (LV) dysfunction, heart failure (HF) and chronic kidney disease (CKD) as disease models, because of their high prevalence in the general population, ...
Improving current cancer detection and treatment follow up through the development of next generation cancer assays. University of Antwerp
ProBio: an outcome-adaptive, multi-arm, open-label, multiple assignment randomized biomarker-driven trial in patients with metastatic castration-resistant prostate cancer Ghent University
Androgen deprivation therapy (ADT) is the Standard systemic therapy for men with advanced prostate cancer. Although initially beneficial, inevitably all patients will progress to the lethal castration-resistant state of the disease. Metastatic castration-resistant prostate cancer (mCRPC) affects approximately 1.500-2.000 men in Belgium every year. Cytotoxic chemotherapy and newer endocrine agents are available, but they are expensive and ...
Improving current cancer detection and treatment follow-up through the development of a next generation cancer assay. University of Antwerp
Improving colorectal cancer detection and treatment follow-up through the development of a novel methylation assay. University of Antwerp
Searching for new leads in the diagnosis of ovarian cancer KU Leuven
Ovarian cancer is a silent killer, metastasizing troughout the abdomen before causing symptoms. A total of 80% of patients will die of the disease. Survival can be ameliorated by screening, improving diagnosis or improving treatment. research so far has invested in optimizing treatment resulting in an increase in overall survival from 18 to 44 months over the last 20 years. Screening has been proven no to be beneficial. optimizing the ...
Linking patient adiposity to tumour microenvironment and therapy response in breast cancer: towards tailored treatment strategies in obesity KU Leuven
This thesis explores innovative translational research approaches in breast cancer, aiming to increase biological understanding of the disease and thereby help advance precision medicine. It does so in two groups of patients with a high clinical unmet need. First, it investigates patients with early breast cancer in the context of adiposity (body fat accumulation). Secondly, it investigates metastatic breast cancer, which is the ultimate ...
Cell-free nucleic acid profiling in diffuse large B-cell lymphoma: a molecular guidance to precision medicine Ghent University
Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype of non-Hodgkin’s lymphomas. DLBCL is an aggressive malignancy that displays major heterogeneity in terms of morphology, genetics and biological behavior. While complete remission is obtained in 70% of cases, patients with refractory or relapsed disease have a poor prognosis. Current classifications fail to identify high-risk subgroups and improve their outcomes. In ...