Projects
Early assessment of chronic kidney dysfunction using contrast-enhanced ultrasound in dogs with primary kidney disease and spontaneous Cushing syndrome Ghent University
Chronic kidney disease, a progressive disorder leading to an irreversible loss of kidney function, is common in older dogs. Early diagnosis is of great importance in improving quality of life. The purpose is to evaluate noninvasive contrast-enhanced ultrasound to detect early perfusion changes in dogs with primary kidney disease and in dogs with spontaneous Cushing’s syndrome.
Development of a cutting-edge service platform for in vivo preclinical testing of drug candidates able to treat chronic kidney disease and its associated co-morbidities. University of Antwerp
New perspectives in the treatment of hyperthyroid cats with radioactive iodine (131I) and in the early detection of kidney failure, a major complication of treatment of hyperthyroidism Ghent University
REcombinant human TSH is used in the treatment of hyperthyroid cats to stimulate thyroid uptake of 131I in order to potentialize treatment and allow a lower dosage of 131I to be used. Kideny function is evaluated through measurements of glomerular filtration ratio after treatment with 131I. Finally urinary markers are assessed as early predictors of renal damage.
Kidney stem/progenitor cells as a potent source for kidney-targeted cell therapy KU Leuven
Research into biomarkers for early detection of Autosomal Dominant Polycystic Kidney Disease KU Leuven
The kidneys, two bean shaped organs located on either side of the spine in the back of the abdomen, are important excretory organs of the human body. Apart from the removal of waste, kidneys have other important functions such as maintaining the blood pressure and the activation of vitamin D. Since these tasks are essential for a healthy life, we can say that a good renal function is vital. Nevertheless, today exist a variety of kidney ...
Innovative ultrasound methods for early diagnosis and detection of consequences in dogs with acute kidney injury Ghent University
Acute kidney injury is the abrupt loss of renal function. It is an import health issue in both human and veterinary medicine, with high mortality rate. The currently used diagnostic techniques are imperfect and do not allow timely diagnosis. The aim of this project is to use contrast-enhanced ultrasound, using both commercially available microbubbles and custom made targeted microbubbles, and elastography in the evaluation of dogs with acute ...
Airborne soot particles and adverse renal outcomes: translocation, kidney functioning and renal graft outcome Hasselt University
The intestinal barrier in patients with chronic kidney disease KU Leuven
Uraemic toxins in children with chronic kidney disease. Ghent University
By a multicenter longitudinal follow-up study, the role of uremic toxins (UT) in the pathogenesis and pathophysiology of chronic kidney disease in children is explored by determining the accumulation pattern of different UT in various renal pathologies and correlating these with comorbidities such as
growth and sleep quality, with CKD progression and the gut microbiome profile.