Projects
Early assessment of chronic kidney dysfunction using contrast-enhanced ultrasound in dogs with primary kidney disease and spontaneous Cushing syndrome Ghent University
Chronic kidney disease, a progressive disorder leading to an irreversible loss of kidney function, is common in older dogs. Early diagnosis is of great importance in improving quality of life. The purpose is to evaluate noninvasive contrast-enhanced ultrasound to detect early perfusion changes in dogs with primary kidney disease and in dogs with spontaneous Cushing’s syndrome.
Cell cycle control in proximal epithelial cells during progression of acute kidney injury to chronic kidney disease in vivo. University of Antwerp
System omics to unravel the gut-kidney axis in Chronic Kidney Disease Ghent University
There is a great need for multi-disciplinary and methodologically well trained scientists in order to unravel complex diseases. Chronic kidney disease (CKD), which is more prevalent in women, and its high risk for cardiovascular disease (CVD) with nearly 50% of all deaths in CKD patients caused by CVD, is such a complex disease and its socio-economic burden is extremely high. STRATEGY-CKD will in this context focus on the gut-kidney axis and ...
Development of a cutting-edge service platform for in vivo preclinical testing of drug candidates able to treat chronic kidney disease and its associated co-morbidities. University of Antwerp
Exploring the apelinergic system in autosomal dominant polycystic kidney disease. Vrije Universiteit Brussel
characterized by the development of renal cysts, represents the 4th
common cause of end-stage kidney disease worldwide. The sole
disease-modifying drug is the vasopressin (AVP) receptor 2
antagonist tolvaptan, but its limited therapeutic effect and significant
side effects warrant novel drugs. The antidiuretic effect of AVP is
counteracted by apelin. ...
Exploring the apelinergic system in autosomal dominant polycystic kidney disease KU Leuven
Autosomal dominant polycystic kidney disease (ADPKD), affecting approximately 1 in 1000 individuals worldwide, is generally diagnosed and treated in adulthood, but renal cysts already originate in childhood. The only current drug disease modifier in adult ADPKD is Tolvaptan, a vasopressin receptor 2 antagonist. However, there is an unmet need for novel drug strategies. While it is often assumed that water excretion is a passive phenomenon, ...
New perspectives in the treatment of hyperthyroid cats with radioactive iodine (131I) and in the early detection of kidney failure, a major complication of treatment of hyperthyroidism Ghent University
REcombinant human TSH is used in the treatment of hyperthyroid cats to stimulate thyroid uptake of 131I in order to potentialize treatment and allow a lower dosage of 131I to be used. Kideny function is evaluated through measurements of glomerular filtration ratio after treatment with 131I. Finally urinary markers are assessed as early predictors of renal damage.
Computerized decision support to assess the kidney function in critically ill patients KU Leuven
In critically ill patients, both increased and decreased renal clearance are highly prevalent and may vary during the course of critical illness. Acute kidney injury is a type of organ failure that is highly prevalent in many conditions that cause severe critical illness, and has an association with worse short- and long-term clinical outcomes. Fluctuations in renal clearance will influence the plasma levels and clearance of renally excreted ...
Kidney stem/progenitor cells as a potent source for kidney-targeted cell therapy KU Leuven
End stage kidney disease (ESKD) is the result of a permanent failure of the kidneys. Kidney failure is caused by the irreversible loss of nephrons, the structural and functional units of the kidney. Although the final patterned and segmented nephrons contain numerous functionally distinct cell types, lineage tracing showed that all these cell types are derived from a SIX2+ progenitor’s population at the kidney cap mesenchyme (CM). The ...