Unravelling the role of ketone body oxidation in lymphagiogenesis KU Leuven
Not much is known about the metabolic mechanism of the lymphangiogenesis (the growth of the lymphatic vessels). According to recent discovery, the fatty acid oxidation (FAO)-derived acetyl-CoA in lymphatic endothelial cells (LECs - the cells lining the lymphatic vessels) is related to this process. Blocking FAO in LECs causes lymphangiogenesis defects and subdermal lymphedema. Since no lymphedema treatment is available, I will investigate if ...