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Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review) KU Leuven Ghent University
Traditionally, non-cancer diseases are not considered as health risks following exposure to low doses of ionizing radiation. Indeed, non-cancer diseases are classified as deterministic tissue reactions, which are characterized by a threshold dose. It is judged that below an absorbed dose of 100 mGy, no clinically relevant tissue damage occurs, forming the basis for the current radiation protection system concerning non-cancer effects. Recent ...
Pathological effects of ionizing radiation: endothelial activation and dysfunction KU Leuven Ghent University
The endothelium, a tissue that forms a single layer of cells lining various organs and cavities of the body, especially the heart and blood as well as lymphatic vessels, plays a complex role in vascular biology. It contributes to key aspects of vascular homeostasis and is also involved in pathophysiological processes, such as thrombosis, inflammation, and hypertension. Epidemiological data show that high doses of ionizing radiation lead to ...
Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET) KU Leuven
Detrimental effects of ionizing radiation (IR) are correlated to the varying efficiency of IR to induce complex DNA damage. A double strand break (DSB) can be considered the simpler form of complex DNA damage. These types of damage can consist of DSBs, single strand breaks (SSBs) and/or non-DSB lesions such as base damages and apurinic/apyrimidinic (AP; abasic) sites in different combinations. Enthralling theoretical (Monte Carlo simulations) ...
Investigation of the impact of ionising radiation on the physico-chemical properties of microparticles in view of non-invasive dosimetry KU Leuven
The research in this PhD covers two dosimeters systems. First, an existing commercial radiochromic radiation dosimeter, and second, a novel non-invasive in-vivo dosimeter system based on ultrasound contrast agents. The first part of the research focuses on GafChromic EBT3 films which become increasingly dark when exposed to ionising radiation. The darkening originates from the formation of light-absorbing diacetylene polymers in the film ...
Improved communication, understanding of risk perception and ethics related to ionising radiation University of Antwerp
In Europe today, institutions, media and the general public exchange information about ionizing radiation and associated risks. However, communication about ionising radiation with the general public has to be further improved, as has been previously highlighted by international responses to the 2011 accident in Japan. This article reports the main activities and findings in this field from the following three FP7 projects: EAGLE, PREPARE and ...
Flowering under enhanced ionising radiation conditions and its regulation through epigenetic mechanisms Hasselt University
As sessile organisms, plants have to deal with unfavourable conditions by acclimating or adapting in order to survive. Regulation of flower induction is one such mechanism to ensure reproduction and species survival. Flowering is a tightly regulated process under the control of a network of genes, which can be affected by environmental cues and stress. The effects of ionising radiation (IR) on flowering, however, have been poorly studied. ...
Lemna minor plants chronically exposed to ionising radiation: RNA-seq analysis indicates a dose rate dependent shift from acclimation to survival strategies Hasselt University University of Antwerp
Ecotoxicological research provides knowledge on ionising radiation-induced responses in different plant species. However, the sparse data currently available are mainly extracted from acute exposure treatments. To provide a better understanding of environmental exposure scenarios, the response to stress in plants must be followed in more natural relevant chronic conditions. We previously showed morphological and biochemical responses in Lemna ...