Understanding intra-tumor heterogeneity in glioblastoma in space and in time. KU Leuven
Intra-tumor heterogeneity is the main obstacle to effective cancer treatment and personalized medicine. The mechanistic underpinnings of intra-tumor heterogeneity in progression and therapeutic resistance are however largely unknown. Single-cell RNA-sequencing (scRNA-seq) has revealed significant inter- and intra-tumoral molecular heterogeneity in Glioblastoma (GBM), an aggressive brain tumor that is obstinate to most therapies. However, this ...