Understanding intra-tumor heterogeneity and its implication in therapeutic resistance with spatial transcriptomics in space and time KU Leuven
Intra-tumor heterogeneity is the main obstacle to effective cancer treatment and personalized medicine. It provides adaptations to response and selection for treatment-resistant subclones. The mechanistic underpinnings of intra-tumor heterogeneity in progression and therapeutic resistance are however largely unknown. Single-cell RNA-sequencing has revealed significant inter- and intra-tumoral molecular heterogeneity in Glioblastoma (GBM), an ...