Projects
Tracing xylem-transported 11C-labelled CO2 in trees: importance and contribution to the carbon metabolism Ghent University
By tracing radioactive 11CO2 in xylem of trees, the contribution of internally transported CO2 will be quantitatively determined with regard to the total carbon budget. Distribution of 11CO2 will be visualized at leaf, branch and stem level using medical imaging (i.e. positron emission tomography, PET). Different tree species will be examined and subjected towards changing atmospheric conditions.
IGF-I and mild hypothermia as new therapies for focal cerebral ischemia Vrije Universiteit Brussel
Ischemic stroke is the most common cause of disability in adults and the 3rd cause of death. It is brought about by a blocked blood vessel in the brain leading to neuronal death. Restoration of circulation via resolution of the blood clot in the vessel by treatment with tissue-type plasminogen activator is the only approved treatment. However, the majority of patients cannot be treated this way. In ...
Distribution and transport of uremic retention solutes: from modelling towards optimisation of hemodialysis Ghent University
Kinetic models for different retention solutes like the protein-bound solutes are calibrated and validated based on in vitro and in vivo data. These models are further used to develop a new parameter to indicate hemodialysis adequacy as well as to optimise and personalise the hemodialysis treatment.
Exploring the endocytic route of ICAM-5 in hippocampal neurons - a strategy to reveal the gamma-secretase independent role of presenilin 1 in protein trafficking. KU Leuven
Mechanisms that regulate intracellular membrane/protein trafficking are of utmost physiological importance. By affecting the delivery of macromolecules to specific external and subcellular sites they impact majority, if not all relevant cellular processes. Not surprisingly, defects in intracellular membrane flow and its regulators are observed in many pathological conditions, including several neurodegenerative disorders (Howell et al., 2006; ...
cytotoxic T cells as transport vehicles for tumor-targeted delivery of nanomedicines Ghent University
Modelling freight consolidation from the perspective of transportation carriers Hasselt University
The Fast-Track to Technological Change: Railways, Market Access and Industrialization in Belgium KU Leuven
The project will for the first time digitize spatially and sectorally disaggregated high-quality census information on labor and output market variables in the various Belgian population, industrial and agricultural censuses and detailed information contained in the historical (light) railway archives for the period 1846-1914. These data are subsequently used to better understand how Belgium’s forerunner role in ‘railwayfication’ has shaped ...
The enigma of subjective lymphedema: Why do patients report lymphedema after breast cancer treatment without an objective measurable swelling? The role of sensory processing and subclinical lymphedema – LymphSens Trial KU Leuven
Breast cancer related lymphedema (BCRL) is one of the most disabling complications of breast cancer treatment. Self-reported BCRL is defined as the diagnosis of lymphedema based on a patient-reported difference in size between the upper limbs. Prevalence rates of self-reported BCRL are higher when compared to objectively diagnosed BCRL. Indeed, up to 40% of breast cancer patients do report signs and symptoms of BCRL but do not have ...