Unraveling defects in the human innate immune response: Diagnosis of inherited disorders in the NF-κB pathway KU Leuven
Primary immunodeficiencies are inherited diseases that predispose children and adults to recurrent bacterial, viral, and/or fungal infections. The awareness for primary immunodeficiencies is still limited in routine clinical practice and many patients are diagnosed too late to prevent life-threatening infections by appropriate therapy. Toll-like/IL-1R (TIR) receptors and the associated NF-κB signaling pathway are important mediators of the ...