Development of an innovative hiPSC-derived cardiac-microtissue-based functional assay to determine the pathogenicity of genetic variants with uncertain significance identified in patients with inherited cardiac arrhythmia; University of Antwerp
Chromatin structure has been shown to play important roles in the orchestration of gene expression programs during development. Spatio-temporal specific cis-regulatory sequences often lie at a long distance from the gene(s) they regulate, requiring spatial chromatin folding to move them in close proximity of their target promoters and fine-tune the time, place and level of gene expression. Interestingly, several whole-genome chromatin ...
IMAGica: an Integrative personalised Medical Approach for Genetic diseases, Inherited Cardiac Arrhythmias as a model Vrije Universiteit Brussel
Inherited cardiac arrhythmias: identification of novel genes and development of a new diagnostic tool for translating genetic diagnosis into precision medicine. University of Antwerp
Understanding inherited and acquired genetic variation in Parkinson's disease through single-cell multi-omics analysis: a unique data resource. KU Leuven
Understanding gene expression pertubation by inheritde genetic variants of GWAS PD-risk loci. Identifying nature and roles of somatic CNV's in PD-etiopathology. Functional characterisation of eQTL and somatically mutated genes