Projects
The role of hemostasis in the pathogenesis of staphylococcus aureus infective endocarditis. KU Leuven
Staphylokinase and staphylocoagulase in infective endocarditis: experimental study in mouse models. KU Leuven
Modulation of bacterial adherence in infective endocarditis: impact of different conduit tissues used in right ventricular outflow tract valve replacement and bacterial surface molecules under shear stress. KU Leuven
Infective endocarditis (IE) is defined as an infection of the endocardial surface of the heart, which may include one or more heart valves, and is lethal if not aggressively treated. IE can have numerous causes, but is a major clinical problem in patients after transcatheter or surgical valve replacement. Treatment of IE is challenged by the high propensity of bacteria, in particular Staphylococcus aureus, to induce inflammatory and ...
Modulation of bacterial adherence in infective endocarditis: impact of bacterial surface molecules and underlying tissues used in right ventricular outflow tract revalvulation. KU Leuven
In terms of therapeutic application, we aim to understand the mechanisms which activate modulation by the extracellular matrix. The emphasis will be on flow-controlled processes, implicating shear stress in tissue-bacterial cross-talk. As a spin-off, we will use various tissues used in right ventricular outflow tract revalvulation to maximally suppress bacteria triggered cell activation, bacterial adhesion and vegetation formation at the ...
Targeting Immunothrombosis in Staphylococcus aureus infections and endocarditis KU Leuven
Proinflammatory and procoagulant response of human vascular endothelial cells in a model of endocarditis - contribution of tissue engineering. KU Leuven
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Targeting Immunothrombosis in Staphylococcus Aureus Infections and Endocarditis KU Leuven
Staphylococcus aureus (S. aureus) is amongst the deadliest infectious pathogens. Its increasing antibiotic resistance has urged the WHO to proclaim it as a top research priority. In contrast to other infections, infective endocarditis (IE) remains highly fatal despite advances in clinical care. With an increasing incidence and an unacceptably high mortality (up to 40%), there is an urgent need to understand how the vegetation, the central ...
The role of NETs in S. aureus endocarditis and systemic thromboinflammation KU Leuven
Restoring the balance in coagulation to improve the outcome of Staphylococcus aureus infection KU Leuven
The epidemic of antibiotic resistance is currently posing a serious threat to our health system. It is estimated that by 2050 over 300 million people will die prematurely as a cause of resistant bacteria. Staphylococcus aureus (S. aureus) is the leader of antimicrobial resistance and the most deadly infectious agent in the developed world. This pathogen is a frequent colonizer of the skin in healthy individuals, but when our immune system ...