RT 20/4 ALTERTOX - Towards risk assessment of Alternaria mycotoxins: comparative in vitro toxicity, and in vivo toxicokinetics in pigs as surrogate animal model for humans Ghent University
ALTERTOX aims to clarify following research questions:
- What is the in vitro cytotoxicity of alternariol, alternariol-monomethylether, tenuazonic acid and relevant mixtures thereof towards intestinal epithelial cells and hepatocytes of human and porcine origin? This will enable the calculation of the mycotoxin concentration at which 50% of the cells show loss in viability (EC50 endpoint), and to determine the ...