Projects

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Multi-drug resistance in malaria in combination therapy : assessment of specific markers and development of innovative, rapid and simple diagnostics Institute of Tropical Medicine

Hendricus SCHALLIG, D'Alessandro
University of Benin, Wageningen University and Research Centre, London School of Hygiene and Tropical Medicine, Centre MURAZ, Kilimanjaro Christian Medical Centre, Koninklijk Instituut voor de Tropen, Amsterdam, Forsite Diagnostics Limited, Institute of Tropical Medicine

General


To assess specific genetic markers for Artemisinin-based combination drugs resistance and the development of innovative, rapid and simple diagnostics.


Specific


To develop and evaluate in disease endemic countries accurate low-tech molecular diagnostic tests for malaria, and evaluate their utility for detecting treatment failure in antimalarial therapy trials.To ...

Post-market surveillance as a tool for assuring quality of in-vitro diagnostics in low-resource settings Institute of Tropical Medicine

Jan Jacobs, Jan Jacobs
Tropical Bacteriology
Post-market surveillance for medical devices (which include in vitro diagnostics (IVDs)) is welldefined and widely implemented in settings with stringent regulatory control but it is relatively nonexistent in low resource settings. Coupled with inadequate pre-market assessment, this leaves testing services in low resource settings extremely vulnerable to supply of IVDs that are poor in terms of quality, safety or performance. Post-market ...

Next generation diagnostics and susceptibility testing in biofilm-related prosthetic joint infections based on a better understanding of biofilm biology – an innovative translational approach Ghent University

Tom Coenye
Department of Diagnostic Sciences, Department of Human Structure and Repair, Department of Pharmaceutical analysis, KU Leuven

There is growing evidence that bacteria form biofilm aggregates in synovial fluid (SF) and surface-attached biofilms on prostheses. If we want to study these biofilms in the context of prosthetic joint infections (PJI) we need better in vitro models. We also need better tools to detect and isolate relevant pathogens from PJI samples as well as novel approaches to better predict clinical success of an antimicrobial treatment. Our preliminary ...

Towards the development of next generation diagnostics and susceptibility testing in biofilm-related prosthetic joint infections Ghent University

Tom Coenye
Department of Pharmaceutical analysis

We aim to optimize and validate relevant in vitro biofilm models by testing them with PJI clinical samples and isolates. Our findings will translate into innovative and clinical applicable approaches for a better diagnosis of PJIs and determination of antimicrobial susceptibility profiles of the microorganisms involved in PJIs. To this end, we propose the following specific objectives:

(i) Further development and validation of ...

Next generation diagnostics and susceptibility testing in biofilm-related prosthetic joint infections based on a better understanding of biofilm biology – an innovative translational approach KU Leuven

Hans Steenackers
Microbial and Plant Genetics (CMPG), Universiteit Gent

Foodborne illnesses remain a significant global public health problem with large economic consequences, despite the strict regulations regarding food safety. Salmonella represents the most common cause of bacterial foodborne outbreaks. We hypothesize that the publicly available exopolymeric substances (EPS) of the biofilm matrix made by this pathogen play an important role in gut colonization and invasion. EPS are therefore considered as ...

New CRISPR-dCas9 toolbox for diverse in vitro and in situ applications: from detecting cancer to cell heterogeneity during embryogenesis KU Leuven

Jeroen Lammertyn
Mechatronics, Biostatistics and Sensors (MeBioS), Department of Human Genetics
The CRISPR – Cas system (stands for: Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR associated, respectively) has been used in a myriad of applications, ranging from genome editing and gene expression modulation to diagnostics and imaging. However, these strategies do not provide signal amplification, and are thus unable to realize sensitive applications. To this end, an engineered CRISPR-dCas9 complex (patent-pending) has ...

GROWSPERM: Development of in vitro and in vivo strategies to avoid and cure male infertility. Vrije Universiteit Brussel

Ellen Goossens
Department of Embryology and Genetics
In many European countries at least 20% of young men exhibit sperm parameters below the lower WHO reference level and this will affect their fertility. Male infertility has a dramatic impact on the individual and couple’s psychological and social well-being and results in significant healthcare costs. Currently male patients that do not produce sperm have no therapeutic options to father children.
Different therapeutic interventions for ...

Evaluation and optimization of a high-throughput sequencing based strategy to detect viruses and bacteria in view of certification and in vitro therapy to create virus free mother plants Research Institute for Agriculture, Fisheries and Food

Emmy Dhooghe, Kris De Jonghe
Plant Sciences
Main research question/goal

The aim of this research project is to produce virus-free starting materials (seeds, cuttings, planting material, tissues...) of commercial crops and to provide the sector with a useful technology to achieve this goal. We focus on crop-specific procedures, based on high-throughput sequencing (HTS), which we evaluate and further optimize for use in both certification (tree nursery and fruit ...

The mutational landscape of in vivo and in vitro human embryogenesis KU Leuven

Joris Vermeesch
Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, Woman and Child

Early human preimplantation development is burdened with chromosome abnormalities. The remarkable genomic instability is predominantly cause by post-zygotic events, which contribute to chromosomal mosaicism. The presence of aneuploidy can be fatal to embryo, causing developmental arrest, implantation failure or adverse pregnancy outcomes. Due to its clinical relevance, the mechanisms and consequences of embryo aneuploidy are being intensively ...

Validation of the Walking Egg in vitro embryo culture system with application in a mobile laboratory setup. Hasselt University

Healthcare & ethics, University of Pretoria
The access to assisted reproductive technology (ART) in the public sector of South Africa will be investigated in this project to determine the demographical profile of patients undergoing diagnostic ART investigations only vs. those who return for therapeutic ART procedures. Secondly, the setting up and application of a "The Walking Egg" (tWE) ART laboratory will be performed. In this section, the embryo development and utilization rates, ...