Immunogenic cell death (ICD) in cancer: From plasticity and discovery of immunogenic determinants to anticancer vaccination. KU Leuven
Most anti-cancer modalities kill cancer cells via physiological apoptosis (a cell death routine that actively suppresses immunity). Recently, certain anticancer drugs were shown to induce an apoptotic routine called immunogenic cell death (ICD) that is immunostimulatory due to the associated emission of immunogenic determinants like calreticulin (CRT) and ATP, which help to stimulate anti-tumor immunity that “vaccinates” the host against the ...