Projects
EXIMIOUS : Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome Hasselt University
Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome KU Leuven
Immune-mediated, non-communicable diseases, such as autoimmune diseases, allergic diseases and asthma, are chronic disorders in which the interaction between exposome and immune system plays a pivotal role. As prevalence and societal costs of these diseases are rising in the EU, a holistic approach is needed.
The EXIMIOUS consortium—gathering high-level experts in immunology, toxicology, clinical medicine, environmental hygiene, ...
Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome KU Leuven
Immune-mediated, non-communicable diseases, such as autoimmune diseases, allergic diseases and asthma, are chronic disorders in which the interaction between exposome and immune system plays a pivotal role. As prevalence and societal costs of these diseases are rising in the EU, a holistic approach is needed.
The EXIMIOUS consortium—gathering high-level experts in immunology, toxicology, clinical medicine, environmental hygiene, ...
CRYPTIC TRANSCRIPTS: THE MASKED HEROES WHO BREAK TUMOR IMMUNE TOLERANCE AND FREE THE RESPONSE TO IMMUNE THERAPY. KU Leuven
In the last years, immunotherapy revolutionized cancer treatment in terms of quality of life and life years saved. Immune-checkpoint blockage (ICB) therapy, like anti-programmed death-1 (anti-PD-1) therapy, blocks the inhibitory interaction between immune-checkpoint ligands on the tumor and their receptors on T-cells (or vice versa). Despite the ground-breaking clinical success, ICB therapy responses are variable and unpredictable, ...
Combining immune stimulation with inhibition of immune suppression to boost innate immunity in cancer. University of Antwerp
Immune system on chip: immune cell interactions with tissue barriers on sensor integrated microfluidic chips. KU Leuven
Microphysiological Systems (MPS) are microfluidic chips that contain multiple cell types and aim to emulate a human organ in a specific context. This is particularly interesting for pre-clinical drug development, given that current practices predominantly rely on animal models or simplified in vitro models. MPS possess a remarkable ability to mimic complex diseases by enabling the study of human cells within dynamic environments. The human ...
A multimodel approach to define conserved immune landscapes behind clinical responses to immune checkpoint blockers in gastrointestinal tumours. KU Leuven
Immune checkpoint blockade has highly variable success depending on the type of cancer. This can partly be remedied by improved biomarkers, but these appear to be very difficult to find due to a lack of insight into the underlying interaction between tumor, immune system and surrounding tissue. One solution is to study these relationships in a structure that covers the entire immunological spectrum through a set of very different anatomical ...