Projects
Nuclear metabolism in the control of cancer cells methylome under hypoxia. KU Leuven
Improving immunometabolic fitness of NK cells in hypoxia to further their functional capacities in the tumor microenvironment. University of Antwerp
Targeting Polo-like kinase 1 for treatment of NSCLC patients: focus on the induction of cellular senescence, the TP53 status and hypoxia. University of Antwerp
Characterisation of epigenetic control of cancer-inflammation by jumonji histone demethylases during hypoxia University of Antwerp
Improving cancer immunotherapy outcome by targeting hypoxia. University of Antwerp
The role of adipose tissue hypoxia in obesity and obstructive sleep apnea. University of Antwerp
Unraveling the role of the hypoxia factor HIF-2a in muscle atrophy. KU Leuven
Skeletal muscle is essential to life as it provides the mechanical power for locomotion and breathing. In our aging population, loss of muscle mass due to long- term inactivity is a major cause of morbidity and mortality. It is also a critical component of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), and although the role of muscle in ALS is debated improving muscle functioning prolongs survival. Thus, preventing ...
Regulation of the central metabolism of pear during hypoxia KU Leuven
The role of biomechanical factors and hypoxia in the induction of chronic tendinitis in spondyloarthropathy. Ghent University
This research project aims to analyze the consequences of frequently occurring stress conditions in joint homeostasis and how these may contribute to chronicity of inflammation in arthritic joint diseases, notably Spondyloarthritis (SpA). The current project therefore aims to unravel the underlying mechanisms of mechanobiology associated inflammation and to explore the role of oxygen levels herein.