The impact of hypoxia on inflammation and tumorigenesis in Ulcerative Colitistrus. KU Leuven
Ulcerative colitis (UC) is a debilitating intestinal inflammatory disorder affecting approximately 1:200 people, the prevalence of which is disproportionately high in Europe. As well as experiencing severe clinical symptoms, 10-18% of UC patients develop inflammation-associated colon cancer. The molecular mechanisms underpinning both the pathology and increased risk of cancer in UC patients remain unclear and effective treatment is a clearly ...