Projects
Investigating the role of DPP6 in neurodegenerative dementia: an hypothesis based approach. University of Antwerp
How T cell autoreactivity develops in early rheumatoid arthritis: the smoking gun hypothesis Ghent University
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases and is characterized by
uncontrolled inflammation of the synovial tissue, eventually leading to joint destruction. RA is a
complex disease resulting by a combination of genetic and environmental factors. The most
profound genetic association exists within MHC-II genes suggesting that RA pathology is Thelper cell
dependent. One of the strongest ...
A new statistical procedure to provide better answers to substantive research questions: analysis of effects combined with informative hypothesis testinG Ghent University
ANOVA is one of the most popular statistical techniques in the social and behavioral sciences.
Unfortunately, the ANOVA framework has some serious drawbacks. First, it does not take the
expectations of the researchers fully into account. For example, researchers may expect that a new
treatment will work better than an old treatment, or that one task is much more difficult than
another, but ANOVA will ignore these ...
The microglial c-'ASC'-ade hypothesis in Alzheimer's disease and related Tauopathies: Microglial ASC inflammasome activation contributes to tau pathology in vivo Hasselt University
Study of the epidemiological impact of the Varicella-zoster virus, the validity of the exogenous boosting hypothesis and the possible implications for public health. University of Antwerp
Statistically and Computationally Efficient Hypothesis Tests for Similarity and Dependency KU Leuven
The dissertation present novel statistically and computationally efficient hypothesis tests for relative dependency, similarity, and precision matrix estimation. The key methodology adopted in this thesis is the class of \ustat estimator. The class of \ustat allows a minimum-variance unbiased estimation of a parameter. We make use of asymptotic distributions and strong consistency of the \ustat estimator to develop novel non-parametric ...
A medieval Stylome? Exploring the Universal Stylome Hypothesis in medieval prose. University of Antwerp
Orchids and dandelions: Meta-analytic and empirical tests of the differential susceptibility hypothesis Ghent University
This project combines meta-analytical and empirical research to purport a more comprehensive test of the differential susceptibility hypothesis, postulating that children vary in their temperamental sensitivity to environmental influences, such as parenting.
Sex hormone binding globulin in men: the free hormone hypothesis revisited during aging and endocrine disorders KU Leuven
Sex hormones (with testosterone as main male sex hormone) belong to the family of steroid hormones. Only the ‘free’ (unbound) fraction is active, but in the circulation these hormones are mainly bound to proteins, with sex hormone binding globulin (SHBG) as most important player. Concentrations of SHBG and thus biological availability of sex steroids change considerably, not only during disease but also during aging. Moreover, the assessment ...