Projects

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Replacement of confocal fluorescence microscope for visualisation of biological processes in humans and animals Ghent University

Hans Nauwynck
Department of Veterinary and Biosciences, Department of Translational Physiology, Infectiology and Public Health, Department of Internal Medicine, Reproduction and Population Medicine

The confocal fluorescence microscope Leica TCS SP2 Laser Scanning Spectral Confocal System, localized in the Laboratory of Virology, Faculty of Veterinary Medicine is a device that is daily used by different users of the Faculties of Veterinary Medicine and Medicine and Health Sciences for the research on different biological processes (pathogenesis, immunopathology, embryology, …). It is ...

IOF Proof Of Concept: Fight bacteria in humans and animals with the MICSTRIP concept Vrije Universiteit Brussel

Hugo Thienpont
Applied Physics and Photonics, Technology Transfer & Interface
Because of the growing concern associated with antibiotic medication and resistance, the World Health Organization emphasizes the need to have effective, rapid, easy-to-use and low-cost diagnostic tools. Since none of the current antibiotic susceptibility testing methods comply with the current needs, a new photonics-based concept was worked-out in a collaboration between Universiteit Antwerpen (Medical Microbiology and Product Development) and ...

Health effects of plant and animal proteins and fibres in human diets Ghent University

Stefaan De Henauw
Department of Public health

To evaluate animal, plant protein and fibre intakes and its associations with obesity indicators in European and Chinese adolescents. European adolescents were recruited in the HELENA-CSS* and Chinese adolescents in the Chinese Health and Nutrition survey. Dietary intakes will be compared with international recommendation and health effects of protein & fibre intakes in the prevention of obesity will be examined.



* ...

Genetic diversity and classification of human and animal rotaviruses. KU Leuven

Marc Van Ranst
Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Rotavirus infections cause more than 600.000 deaths in children each year. Rotaviruses have a segmented genome consisting of 11 segments of double-stranded RNA encoding 6 structural (VP) and 6 non-structural (NSP) proteins. VP7 and VP4 form the outer capsid of the rotavirus and are used for a dual classification system defining respectively G and P-genotypes. Currently, the most common human rotavirus genotypes worldwide are G1P[8], G2P[4], ...

Simultaneous detection and identification of viral pathogens from human, animal, plant and invertebrate hosts using DNA arrays. KU Leuven

Kris Willems
Bioengineering Technology, Group T Leuven Campus
Detection of viral pathogens is of critical importance in several domains, including biology, medicine, agriculture, aquaculture, and food processing. Historically, common methods for virus detection have relied upon isolation and in vitro culture, or immunological assays, or, more recently, on nucleic acid based detection assays. One limitation of most detection procedures, however, is that only a single or few targets of interest can be ...

The Tendon Trap: an innovative surgical technique for the repair of lacerated circular tendons in both human and animal species. Ghent University

Lieven De Wilde
Department of Human Structure and Repair, Department of Physical medicine and orthopaedic surgery

A new repair technique in the treatment of ruptured tendons in Orthopaedic and Veterinary surgery will be studied through biomechanical testing on both animal and human cadaveric tendons. If successful, we will proceed to a clinical study on sheep as a model for human medicine. Main goals are a better functional outcome, faster rehabilation and a decrease in cost.

From exposome to effect assessment of contaminants in human and animal models (EXPOSOME). University of Antwerp

Adrian Covaci
Ecosphere, Behavioural Ecology & Ecophysiology, Veterinary physiology and biochemistry, Institutional Research Unit, Systemic Physiological and Ecotoxicological Research (SPHERE), Laboratory Experimental Medicine and Pediatrics (LEMP), Toxicological Centre
We will develop a pioneering holistic framework based on innovative approaches to explore the human exposome in terms of exposure leading to adverse effects with a focus on endocrine-modulated neurological and metabolic disorders by:i. Identifying and characterizing the exposure sources of relevant chemicals in the context of the xposome framework;ii. developing and applying in silico, in vitro and in vivo human and animal models to investigate ...

Blood cell counts in human and animal research KU Leuven

Kathleen Freson
Centre for Molecular and Vascular Biology
Clinicians often rely on complete blood counts (CBC) to monitor overall health, to screen for some blood and other diseases, to confirm a diagnosis of some medical condition and to monitor changes in the body caused by therapies. A CBC is the most commonly performed blood test in medicine but also for research including the use of different animal models, CBCs are frequently determined to address similar aspects. The CBC immediately determines ...

Environmental, animal and human health in Madagascar: A One Health approach to protected area management KU Leuven

Ellen Decaestecker
Biology, Kulak Kortrijk Campus, Ecology, Evolution and Biodiversity Conservation

This project aims to investigate the negative feedback of anthropogenic factors to animal and human health in screening disease in lemurs and domestic animals, and to provide a better understanding for stakeholders and decision-makers, giving them more insight into how this is linked with actual Protected Area (PA) management in Madagascar. The specific objectives are: (i) To characterize microbiomes and to detect potential (re)emerging ...

Precision medicine in inherited blindness using integrated omics in human and animal models Ghent University

Björn Menten, Lieven Clement, Kris Vleminckx, Bart Leroy, Elfride De Baere
Department of Applied Mathematics, Computer Science and Statistics, Department of Pharmaceutics, Department of Biomedical molecular biology, Department of Head and Skin, Department of Biomolecular Medicine

This multidisciplinary project aims (1) to decipher cis-­regulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-­based treatments of novel targets, ultimately resulting in precision medicine ...