Human fetal microglia acquire homeostatic immune-sensing properties early in development Ghent University
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution Ghent University
A homologous form of human interleukin 16 is implicated in microglia recruitment following nervous system injury in leech hirudo medicinalis Ghent University
Single-nucleus RNA-Seq is not suitable for detection of microglial activation genes in humans University of Antwerp KU Leuven
Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits Vrije Universiteit Brussel KU Leuven
BACKGROUND: Microglia play a central role in most neurological disorders, but the impact of microgliosis on brain environment and clinical functions is not fully understood. Mice lacking multifunctional protein-2 (MFP2), a pivotal enzyme in peroxisomal β-oxidation, develop a fatal disorder characterized by motor problems similar to the milder form of MFP2 deficiency in humans. The hallmark of disease in mice is the chronic proliferation of ...
The endoplasmic reticulum Ca2+-ATPase SERCA2b is upregulated in activated microglia and its inhibition causes opposite effects on migration and phagocytosis KU Leuven
Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex KU Leuven
Neuronal Dysfunction and Behavioral Abnormalities Are Evoked by Neural Cells and Aggravated by Inflammatory Microglia in Peroxisomal β-Oxidation Deficiency Vrije Universiteit Brussel KU Leuven
It is becoming evident that microglia, the resident immune cells of the central nervous system (CNS), are active contributors in neurological disorders. Nevertheless, the impact of microgliosis on neuropathology, behavior and clinical decline in neuropathological conditions remains elusive. A mouse model lacking multifunctional protein-2 (MFP2), a pivotal enzyme in peroxisomal β-oxidation, develops a fatal disorder characterized by motor ...