The impact of radiotherapy on the human connectome and neurocognitive outcome in pediatric brain tumor patients: towards neuroimaging-guided treatment optimization KU Leuven
For pediatric brain tumor patients, cranial irradiation is known to result in long-term neurocognitive decline. Although radiation-induced neurotoxic mechanisms are hypothesized, the pathophysiology and the extent of neurological damage remains poorly understood. Given the rapidly evolving innovative treatments, optimization of brain tumor treatment requires a good estimation of the extent and dose-dependency of neural damage due to cranial ...