Projects
ATMP Center: custom quality control & GMP services for clinical ATMP development Hasselt University
The role of plasmin in thrombotic thrombocytopenic purpura (TTP) KU Leuven
In a recent study, we demonstrated that the proteolytic enzyme plasmin is capable of destructing VWF multimers in vitro, and that plasmin becomes activated in patients during acute TTP episodes. In this project, we will investigate why plasmin is activated during acute TTP and why it is not sufficient to prevent TTP episodes. Furthermore, we will investigate what the effect of endogenous plasmin inhibition and activation is on the severity of ...
Gene therapy for thrombotic thrombocytopenic purpura (TTP) KU Leuven
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening microangiopathic disorder caused by a severe deficiency in the plasma metalloprotease ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 repeats, member 13). This disease is characterized by von Willebrand factor (VWF)- and platelet-rich microthrombi, thrombocytopenia and haemolytic anemia with schistocytes.
In about 5% of the TTP patients, the ...
development of quality framework for online help WVG Arteveldehogeschool
Hemp as a driver of circularity in the textile industry: from field to recycled fibre HOGENT
Digital Tools to help Agroforestry meet climate, biodiversity and farming sustainability goals: linking field and cloud Research Institute for Agriculture, Fisheries and Food
The performance of agroforestry is highly context-dependent. Several issues hinder large-scale adoption, such as lack of a conclusive regulatory framework. In addition, tools are lacking to reliably assess the economic, environmental and social assets of agroforestry, and to use these insights for smart design and optimal management of agroforestry systems. Tools to monitor and adjust the impact of policy ...