Publications
Hepatic vagotomy inhibits proliferation of hepatic stellate cells in rats with acute hepatitis KU Leuven
Distinct roles for non-muscle myosin II isoforms in mouse hepatic stellate cells. Vrije Universiteit Brussel
invertebrate and mammalian muscle preparations containing non-muscle myosin. Activated hepatic stellate cells have contractile
properties and play an important role in the pathophysiology of liver fibrosis and portal hypertension. Therefore, hepatic
stellate cells are considered as therapeutic target cells. ...
Mycophenolic acid induces apoptosis of hepatic stellate cells in an in vitro model of HCV Vrije Universiteit Brussel
INTRODUCTION: Hepatitis C virus (HCV) infection is an important risk factor for the development of liver fibrosis and progression to cirrhosis. Liver transplantation as terminal treatment option for liver disease requires life-long immunosuppression. However, immunomodulatory therapy may promote reinfection and renewed fibrogenesis. Immunosupressive agents may also affect the life cycle of hepatic stellate cells (HSC), the main source of ...
Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells Vrije Universiteit Brussel
Adult-derived human liver stem/progenitor cells (ADHLSC) are obtained after primary culture of the liver parenchymal fraction. The cells are of fibroblastic morphology and exhibit a hepato-mesenchymal phenotype. Hepatic stellate cells (HSC) derived from the liver non-parenchymal fraction, present a comparable morphology as ADHLSC. Because both ADHLSC and HSC are described as liver stem/progenitor cells, we strived to extensively compare both ...
Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells Vrije Universiteit Brussel
Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo Vrije Universiteit Brussel
Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells Vrije Universiteit Brussel KU Leuven
BACKGROUND & AIMS: Liver fibrogenesis - scarring of the liver that can lead to cirrhosis and liver cancer - is characterized by hepatocyte impairment, capillarization of liver sinusoidal endothelial cells (LSECs) and hepatic stellate cell (HSC) activation. To date, the molecular determinants of a healthy human liver cell phenotype remain largely uncharacterized. Here, we assess the transcriptome and the genome-wide promoter methylome ...
(+)-Catechin attenuates activation of hepatic stellate cells Vrije Universiteit Brussel
(+)-Catechin is a type of catechin present in large amounts in açaí fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor γ mRNA ...