Projects

We aim to study the introduction of novel technologies, such as vNOTES and vaginal laser application, into our gynaecologic practice. For vNOTES hysterectomy, we will study the learning curve, perform a cost minimisation study, and measure the impact of an enhanced recovery protocol on hospital stay. In breast cancer patients under AI, we will perform a randomized controlled trial comparing fractional CO2 vaginal laser to hyaluronic acid ...

Minimally invasive surgery is growing rapidly in various domains, including benign gynaecological surgery. This stems from the advantages for the patient, such as less morbidity, better postoperative quality of life and a shorter interval to regaining normal functioning. But also the societal burden diminishes by omitting or shortening the need for overnight hospitalisation, and by enhancing a quicker return to work. We strive to optimize ...

Here, we aim to set up a Phase II, multicenter study to test the efficacy of Fulvestrant in patients with ER-positive low-grade gynecological cancers. Fulvestrant is an anti-ER drug already approved for ER-positive metastatic breast cancer in postmenopausal women progressing under previous endocrine treatments. Because of its peculiar mechanisms of action, there are indeed high
chances that tumors developing resistance to other hormone ...

The objective of the thesis is to develop knowledge on gynecologic ultrasound. Specifically I will concentrate myself on the fields of artificial intelligence and three- dimensional ultrasound applied to the ovarian cancer first and later also focus on the three- dimensional ultrasound to endometrial cancer and uterine malformations. I will participate in the already ongoing research projects and take the chance to start new projects based on ...

Ovarian cancer is the fifth most common cancer in women and it accounts for the highest rate of gynecological cancer-associated deaths. A major problem is that often, at the time of diagnosis, patients present with advanced state disease. The first line treatment for ovarian cancer consists of standard platinum treatment. Although a large fraction of patients initially respond to the treatment, their tumors often develop resistance and ...

EFFECT (EFFectiveness of Endometrial Cancer Treatment): A study on the quality and effectiveness of the care for endometrial cancer in Belgium.

With 78.920 newly diagnosed cases in 2018, corpus uteri cancer (i.e. uterine cancer, cervix uteri excluded) is the fourth most common cancer in European women after breast, colorectal and lung cancer. Furthermore, it is also the most common gynecologic cancer, preceding ovarian and cervical ...

Glucose homeostasis, metabolomics and pregnancy outcomes after bariatric surgery: the GLORIA study The prevalence of obesity and metabolic syndrome is increasing at an alarming rate worldwide. Obesity in women is associated with infertility and miscarriages. During pregnancy, obesity is associated with increased risk of gestational diabetes mellitus (GDM), preeclampsia, macrosomia and caesarean delivery. For women with a body mass index (BMI) ...