Projects
MYCOGUT: Mycotoxins and gut microbiota, an unresolved interplay towards human chronic low-grade gut inflammation Ghent University
There is an urgent demand to investigate combined effects of multiple mycotoxins over the life course on alterations of the gut microbiota and the development of chronic low-grade gut inflammation through observational studies. Mycotoxins are secondary metabolites produced by toxigenic fungi that contaminate food and feed. Practically everyone undergoes chronic, low-dose, variable dietary exposure to mycotoxins throughout their lives, but ...
SPIDER: Spondyloarthritis Precursors In first DEgree Relatives. Identifying gut microbiome alterations and early signs of subclinical gut inflammation in family members of spondyloarthritis patients Ghent University
MoodBugs: How our gut microbes influence how we feel - bacterial metabolites and inflammation as mediators of human microbiota-affect relationships KU Leuven
Do our gut microbes influence our emotions? This sounded far-fetched a decade ago, but rodent research has shown that the microbial ecosystem in the gut (the gut microbiota) causally impacts affective processes. The underlying microbiota-gut-brain signalling mechanisms include the capacity of the microbiota to produce short-chain fatty acids (SCFA) from dietary fiber and to regulate inflammation.
These rodent findings have great ...
MoodBugs: "How our gut microbes influence how we feel – bacterial metabolites and inflammation as mediators of human microbiota-affect relationships" KU Leuven
Do our gut microbes influence our emotions? This sounded far-fetched a decade ago, but rodent research has shown that the gut microbiota causally impacts affective processes. The underlying microbiota-gut-brain signaling mechanisms include the capacity of the microbiota to produce short-chain fatty acids (SCFA) from dietary fiber (DOI: 10.1038/s41575-019-0157-3), and to regulate inflammation. These rodent findings have great potential to ...
Dynamic modulation of disease progression in chronic gut and joint inflammation in spondyloarthritides Ghent University
In this proposal the relation between gut and joint inflammation in spondyloarthritis is investigated by examininng the underlying cellular and molecular mechanisms of inflammation with focus on mechanical strain and immune regulation. Through miniature ecosystems, i.e. pre-adapted microbial cocktails, we aim to boost immune regulatory mechanisms thereby altering the disease course.
Dynamic modulation of disease progression in chronic gut and joint inflammation in spondyloarthritides Ghent University
In this proposal the relation between gut and joint inflammation in spondyloarthritis is investigated by examininng the underlying cellular and molecular mechanisms of inflammation with focus on mechanical strain and immune regulation. Through miniature ecosystems, i.e. pre-adapted microbial cocktails, we aim to boost immune regulatory mechanisms thereby altering the disease course.
Exploring the Gut-Muscle axis in sarcopenia: The TEMPUS-FUGIT study (Trial in Elderly with Musculoskeletal Problems due to Underlying Sarcopenia - Faeces to Unravel Gut and Inflammation Translationally) KU Leuven
Sarcopenia, the age-related loss of muscle mass and function, is a hot topic, because of the adverse outcomes such as immobility, falls and death, and because its prevalence increases due to the ageing population. There is growing interest in the role of the gut flora in healthy aging, and an unhealthy gut flora has been linked to diseases such as dementia, depression and asthma. It is also clear that the gut flora influences muscle ...
Dynamic modulation of disease progression in chronic gut and joint inflammation in spondyloarthritides Ghent University
In this proposal the relation between gut and joint inflammation in spondyloarthritis is investigated by examininng the underlying cellular and molecular mechanisms of inflammation with focus on mechanical strain and immune regulation. Through miniature ecosystems, i.e. pre-adapted microbial cocktails, we aim to boost immune regulatory mechanisms thereby altering the disease course.
Dynamic modulation of disease progression in chronic gut and joint inflammation in spondyloarthritides Ghent University
In this proposal the relation between gut and joint inflammation in spondyloarthritis is investigated by examininng the underlying cellular and molecular mechanisms of inflammation with focus on mechanical strain and immune regulation. Through miniature ecosystems, i.e. pre-adapted microbial cocktails, we aim to boost immune regulatory mechanisms thereby altering the disease course.