Gut inflammation in axial spondyloarthritis patients is characterized by a marked type 17 skewed mucosal innate‐like T cell signature Ghent University Flanders Institute for Biotechnology
Objective: SpA patients often present with microscopic signs of gut inflammation, a risk factor for progressive disease. We investigated whether mucosal innate-like T-cells are involved in dysregulated interleukin (IL)-23/IL-17 responses in the gut-joint axis in SpA. Methods: Ileal and colonic intraepithelial lymphocytes (IEL) and lamina propria lymphocytes (LPL), and paired peripheral blood mononuclear cells (PBMC), were isolated from ...