Characterization and analysis of in vivo intracranial models for glioblastoma KU Leuven
Glioblastoma (GBM) is the most aggressive intrinsic brain tumor in adults. In spite of maximal therapy consisting of surgery, radiotherapy and chemotherapy, GBM remains largely incurable with a median overall survival of less than 15 months. GBM is commonly characterized by complex chromosomal aberrations, while exhibiting a moderate mutational burden compared to other cancer types, all of which target a multitude of pathways. Also, the ...